Coronavirus Pandemic

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Re: Coronavirus Pandemic

Post by gilesgoat »

KlaxonCow wrote:Ominous milestone.

Thanks to an Omicron surge in many countries, global daily cases has broken a million.

1.2 million, which is actually quite a significant leap from the previous record of ~900K daily cases.

But, despite this, the global daily deaths hasn't really budged - and continues on a very gradual decline, in fact. Although, yeah, we need a few more weeks to be sure that all these new cases aren't really leading to more hospitalisations and deaths.

And, really, the big thing with Omicron is to see it in the global perspective - recognising that there are many countries that cannot mount grand vaccination campaigns, like the richer nations can - and that if Omicron is less lethal, even amongst the unvaccinated / under-vaccinated, then that's really what we need. As, on a global level, there'll always be some people who'll be unvaccinated / under-vaccinated through poverty.

Because, you know, this is a global pandemic and we need to recognise that even if we're doing awesome in our own countries, then we can still be knocked sideways by things going horribly wrong elsewhere. E.g. Omicron comes from South Africa.

(But I will give politicians some slack that it really is a near-impossible call. Do you keep doses for your own population in case of a surge, or do you donate any excess to poorer nations? Because that is also in our collective interest, to make sure that the virus doesn't simply set up its "breeding grounds" in some other nation, which'll then come back to us in the future. I couldn't make that call either. Because it's essentially "futurology" - guessing what might happen - and there's no way to know if you're actually doing the right thing or not. That said, the logic, therefore, is that we should all "hedge our bets" a little. A little of column A and a little of column B. If we don't know which future is coming, at least we can be half-prepared for both? And, certainly, if things get back to a significant decline, then start shipping the excess out to other nations. But I'll grant the politicians a pass that this is basically one of those "you can't win" fuzzy decisions that I don't envy them having to make.)

What about "richer nations get together start all they can to give doses to poorer nations" ?

Because "if they get sick, we get sicker too" and nobody should be sick if something can be done.
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Re: Coronavirus Pandemic

Post by Ollie »

It's not about how many vaccine doses the rich countries will deign to donate to poorer nations, it's about waiving the patents so the rich countries don't get to decide whether and how many the poorer nations get.
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Re: Coronavirus Pandemic

Post by KlaxonCow »

Ollie wrote:It's not about how many vaccine doses the rich countries will deign to donate to poorer nations, it's about waiving the patents so the rich countries don't get to decide whether and how many the poorer nations get.
I completely agree with you.

That's why I was annoyed at AZ getting all the flak, when they - along with Johnson & Johnson - pledged to be "not for profit" on their vaccine, while Pfizer and Moderna flatly refused to do the same.

Particularly because, by the evidence, there's barely any difference between AZ and Pfizer's blood clot numbers - and all the vaccines reduce the chance of blood clots significantly.

Here's the BMJ's infographic that shows the actual numbers on various types of blood clots:

Image

As you can see, in every single case, vaccination with AZ (the violet-y purple) and with Pfizer (orange) reduce - in some cases, very substantially reduce - the chances of blood clots, in comparison to natural infection (the pinky purple).

There's very little difference - just "margin or error" stuff - between AZ's results and Pfizer's results, as you can see. Pfizer is mostly slightly better - though AZ has better numbers on Ischaemic Strokes and "other" - but there's really fuck all of significance between them. You can see that, for most of these, bar the top two listed, you could not get a hair between them (and that's, like, "margin of error" stuff - redo the numbers again and they could easily swap places).

So, the headline "vaccines cause blood clots" is simply utter bullshit. Covid - or, perhaps more precisely, the immune response to it (or the vaccines, which are simulating the virus) - causes blood clots. ALL the vaccines reduce the chance of that happening (in many cases, very substantially so).

And there's simply nothing here in these figures to suggest you should ban AZ, while happily carrying on Pfizer jabs. There's barely anything between them, so how the hell can any of these political bans on AZ be justified by the evidence? They absolutely can't.

But the way all the EU countries lined up to club AZ on the head - and other nations like the UK and the US have also "gone cold" on AZ because of the adverse publicity - while no-one said a single sodding thing about Pfizer at any point?

I was suspicious as hell of this.

The company that refuses to do this "not for profit". The company that, you know, is selling its jabs at $14 (US price) to $15 (EU price) per shot, where AZ's charging $2.15 to $5 per shot (and the numbers have leaked, the costs of production are broadly similar, Pfizer's just adding a big profit margin on top). This is the company escaping all criticism as if utterly perfect, while AZ is slurred and banned all over the place - for what we can see is basically no real difference in results, and ALL vaccines reduce the chance of blood clots. NONE of them are causing it - Covid is causing the blood clots and the vaccines reduce the chance, but they don't, unfortunately, reduce that chance to zero.

That's the actual conclusion from real figures, supplied by actual doctors.

The vaccines - all of them - are vastly better than taking your chances with Covid itself. From actual real world data. And, come on, in the climate we've been living in, with the surges we've seen, if you're not getting the vaccine then you're likely going to eventually get Covid (because, yes, there is the idea that you could not get any vaccine and avoid Covid too, then your chances of blood clots are zero - but that's not reality and that's not sensible, is it? Because you're probably not going to avoid Covid, and then you've just made your chances significantly worse. Besides the fact that, you know, Covid also kills through pneumonia and cripples people for long periods of time with Long Covid and can cause permanent damage, even to survivors, on top of the blood clot chance as well). Because, heck, even with the vaccines, we're getting "breakthrough" infections on Delta, and Omicron seems to give far less shits about vaccine immunity.

And there's even some proof, from a Channel 4 investigation, that Pfizer has actually been paying experts to lie about Astrazeneca's jab:

https://www.wionews.com/world/investiga ... jab-435463

This isn't a "smoking gun" over the bullshit with AZ and the EU, unfortunately - it's a different incident - but they were paying experts to bullshit that AZ's jab has possible cancer links. Oh, yes, they sunk exactly that low.

Pfizer are also forcing governments - such as the UK government - to sign secrecy clauses, to protect their sales numbers and prices from public scrutiny, before they'll supply jabs (as the UK did fuck up and published a "redacted" document that, oops, didn't redact the numbers properly, so the government itself accidentally leaked all the numbers for each of the jabs last Summer).

They're expected to make revenues of £36 billion on their jab. The estimate on AstraZeneca is about $2-3 billion. And that's revenue, not profits, so if you deduct costs (which, as I say, have leaked and are broadly the same for all the jabs), then AZ is keeping to its pledge that it's not trying to profiteer, while Pfizer are pointing at us all and laughing.

Pfizer are cunts. They're blatantly profiteering - and even making governments sign "secrecy clauses" to hide this fact from general public view. The evidence completely exonerates AZ's jab. The bans were political bullshit, from a company that's already been caught paying experts to lie about AZ already.

So, you know, don't remotely get me wrong here. I 100% fully agree with you.

But, well, realism. We can say "drop the patents" all we like, but it's never going to happen. Pfizer's got $36 billion in the bank to make sure that it's never going to happen.

That's what should happen. But, being realistic, it's not going to happen and so, you know, I was offering the "next best" in light of this. Pfizer's never going to drop its profiteering stranglehold, so the "next best" is that rich nations help out poorer ones. Because that, with some political pressure, could happen.
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Re: Coronavirus Pandemic

Post by Harlequin »

KlaxonCow wrote:… I was annoyed at AZ getting all the flak, when they - along with Johnson & Johnson - pledged to be "not for profit" on their vaccine, while Pfizer and Moderna flatly refused to do the same.
…
But, well, realism. We can say "drop the patents" all we like, but it's never going to happen. Pfizer's got $36 billion in the bank to make sure that it's never going to happen.

That's what should happen. But, being realistic, it's not going to happen and so, you know, I was offering the "next best" in light of this. Pfizer's never going to drop its profiteering stranglehold, so the "next best" is that rich nations help out poorer ones. Because that, with some political pressure, could happen.
That may be Pfizer's story but why are AZ and J&J unlikely to relax their patents (or freely license for a while)?
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Re: Coronavirus Pandemic

Post by KlaxonCow »

Harlequin wrote:That may be Pfizer's story but why are AZ and J&J unlikely to relax their patents (or freely license for a while)?
Because, like, all of "Big Pharma" are a bunch of cunts.

I ain't saying that everyone else is angelic here. Just, like, Pfizer is the biggest cunt of the lot - you know, their revenue is looking to be $36 billion, while AZ, at most, is predicted to be $3 billion.

Both figures are obscene. But Pfizer's is literally an order of magnitude worse, for something that - production-costs-wise - ought to be essentially the same price.

There are no "good guys" here, I'm afraid. But AZ and J&J did try to create a pact to not profiteer from a pandemic - but Pfizer and Moderna just flatly refused to join, reserving the right to profiteer as much as they could.

And the bullshit thrown at AZ is simply NOT justified by the actual evidence - as you can see from that BMJ infographic - yet we all saw them get clubbed over the head repeatedly by EU countries, while Pfizer completely escaped any criticism whatsoever (despite their data barely being any different to AZ's).

They're all arseholes. But some arseholes are worse than others.
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Re: Coronavirus Pandemic

Post by KlaxonCow »

April 2020:


June 2020:


October 2020:


December 2020:


Anniversary interlude (April 2021):


August 2021:



Hopefully, there won't be any more parts to this series. Hopefully.
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Re: Coronavirus Pandemic

Post by The ghost of raids past »

KlaxonCow wrote:
Harlequin wrote:That may be Pfizer's story but why are AZ and J&J unlikely to relax their patents (or freely license for a while)?
Because, like, all of "Big Pharma" are a bunch of cunts.

I ain't saying that everyone else is angelic here. Just, like, Pfizer is the biggest cunt of the lot - you know, their revenue is looking to be $36 billion, while AZ, at most, is predicted to be $3 billion.

Both figures are obscene. But Pfizer's is literally an order of magnitude worse, for something that - production-costs-wise - ought to be essentially the same price.

There are no "good guys" here, I'm afraid. But AZ and J&J did try to create a pact to not profiteer from a pandemic - but Pfizer and Moderna just flatly refused to join, reserving the right to profiteer as much as they could.

And the bullshit thrown at AZ is simply NOT justified by the actual evidence - as you can see from that BMJ infographic - yet we all saw them get clubbed over the head repeatedly by EU countries, while Pfizer completely escaped any criticism whatsoever (despite their data barely being any different to AZ's).

They're all arseholes. But some arseholes are worse than others.
You fail to understand the sheer cost of research of any new medicine. Firstly you have the raw cost of the research, then if that research bears fruit you have to be gin clinical trials and then if that succeeds then you have a product to sell

For every successful drug there are many costly failures. The rate of failure is large, failing at clinical trials means a huge research effort comes to naught. You as a bystander see only the tip of the iceberg and never know or experience the vast ammount of underpinning work.
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Re: Coronavirus Pandemic

Post by Cloudane »

The likes of Pfizer ruin it for everyone as it seems the antivax "big pharma" conspiracy theories don't come from nowhere, they exist because we do have some pretty evil lot with actual conspiracies. So here we have genuinely important vaccines we really do need but trust in these companies and their motivations is pretty damn low. Add in feelings of denial, "I seem to have got away fine without it" and a dash of contrarianism and boom, antivax.


In other news, watched the first of the Christmas Lectures on the subject last night. Aimed at kids obviously but very interesting still and there are a lot of adults who could do with seeing it. Of course, the ones who will take enough of an interest to see it are not the same people who most need to see it...
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Re: Coronavirus Pandemic

Post by Orava »

I have worked with big pharma* and yes their motivations are purely monetary. "Can we make this product to have one more claim?". But it is very strictly monitored (or used to be before brexit) a single study to make a claim for a pain killer to be effective against headache taking something like two years.

*and having to check your car for planted bombs by animal enthusiasts is no joke either
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Re: Coronavirus Pandemic

Post by gilesgoat »

The ghost of raids past wrote:
KlaxonCow wrote:
Harlequin wrote:That may be Pfizer's story but why are AZ and J&J unlikely to relax their patents (or freely license for a while)?
Because, like, all of "Big Pharma" are a bunch of cunts.

I ain't saying that everyone else is angelic here. Just, like, Pfizer is the biggest cunt of the lot - you know, their revenue is looking to be $36 billion, while AZ, at most, is predicted to be $3 billion.

Both figures are obscene. But Pfizer's is literally an order of magnitude worse, for something that - production-costs-wise - ought to be essentially the same price.

There are no "good guys" here, I'm afraid. But AZ and J&J did try to create a pact to not profiteer from a pandemic - but Pfizer and Moderna just flatly refused to join, reserving the right to profiteer as much as they could.

And the bullshit thrown at AZ is simply NOT justified by the actual evidence - as you can see from that BMJ infographic - yet we all saw them get clubbed over the head repeatedly by EU countries, while Pfizer completely escaped any criticism whatsoever (despite their data barely being any different to AZ's).

They're all arseholes. But some arseholes are worse than others.
You fail to understand the sheer cost of research of any new medicine. Firstly you have the raw cost of the research, then if that research bears fruit you have to be gin clinical trials and then if that succeeds then you have a product to sell

For every successful drug there are many costly failures. The rate of failure is large, failing at clinical trials means a huge research effort comes to naught. You as a bystander see only the tip of the iceberg and never know or experience the vast ammount of underpinning work.
I know someone that knew a bit of something of this.

He told me that "pharmacological research" costs "a really huge amount of money" .. really huge .. so huge that "Big Pharma" are "the only one that can do it" and "if they don't make enough profit" they are NOT going to do it.

But even this "is a partial story" because we should also check/see "how much money governments give them to do some stuff" ? If the answer is "close to nothing" then "you are kinda fucking yourself with your own hands" .. if it's something "there's something that could be said here".

However I THINK there should be "at least in place some laws" that says "fine, but once you re-gained your profits you could start 'discounting' the stuff" ..

There's also another "big pharma problem" that is someway worse than vaccines .. there are illnesses really rare which there's no cure yet .. because they are so rare that despite maybe hitting some 10,000 people "they are too small to justify research/development of a cure for those" .. so that stuff is NOT "primary concern" .. "too small" in the sense "even if we cure all those 10,000 people we are NEVER going to see our investement back"..

"Big Pharma" is NOT "state controlled" nor is a charity is a PROFIT organization with investors that want their money back.

It's a bit weird "they are not just to cure people, they are to cure people AND make money with the 'make money' first".

"In a perfect world", I SUPPOSE, all host "pharma" would be state controlled, state financed, with the goal to find the best possible medicines at the lowest possible prices and available to everyone.

But reality is FAR from this, so there you go.

Ultimately those people are there to make money too and having to go with their own money.

You'd need much different legislastion I suppose and MUCH MORE government intervention/power to make "more changes" but that would mean "LOT more Socialism, LOT LESS capitalism, much more government control".

And if they government "does shit" you are still royally fucked up ...
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Re: Coronavirus Pandemic

Post by tufty »

Its not big pharma who have the say so on the enforceability of patents. Just saying.
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Re: Coronavirus Pandemic

Post by Ollie »

I thought they did get a shitload of government money to help with the Covid vaccine development. At the very least they got masses of pre-orders and no marketing costs (apart from whatever Pfizer spent on telling lies about AstraZeneca).
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Re: Coronavirus Pandemic

Post by KlaxonCow »

The ghost of raids past wrote:You fail to understand the sheer cost of research of any new medicine.
You fail to understand what the word "profit" means.

Profit is revenue minus costs.

So bringing up costs is an irrelevancy here, as no-one is asking anyone to do this out-of-pocket.
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Re: Coronavirus Pandemic

Post by The ghost of raids past »

KlaxonCow wrote:
The ghost of raids past wrote:You fail to understand the sheer cost of research of any new medicine.
You fail to understand what the word "profit" means.

Profit is revenue minus costs.

So bringing up costs is an irrelevancy here, as no-one is asking anyone to do this out-of-pocket.
Profit from one drug supports the future research costs of failed enterprises
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Re: Coronavirus Pandemic

Post by Rhythm »

Personal rant time. Why the fuck is it that people have questioned everything Johnson has done for the past couple of years but as soon as he says "go on, have a party" everyone's suddenly "yay, go Boris!".

Currently stuck in stupid shit piles between the two families I'm involved in (ex and my kids, GF and hers). Ex has agreed to take our eldest to a NYE party tonight, and GF's 18 y/o has taken it upon herself to invite a bunch of mates to the house for a gathering. Ex and GF both know these are bad decisions but feel trapped into agreeing they can go ahead because all the news says so and lord knows there's been precious little partying/socialising over the past couple of years.

Ex taking my kid - mild exposure risk (small family party) and if need be I can avoid seeing them for a couple of days whilst I figure out if they've come down with anything.

GF's daughter - more complicated. 8-10 18+ kids descending on the house after having spent their week who the hell knows where. All exacerbated by the fact that GF has asthma, isn't allowed the booster and is currently suffering from pneumonia. I sent her daughter a message telling her how scared I was and that she might want to think about rescaling the event but I've just had shitty responses because now I'm just some killjoy stepdad.

Fucking awesome end to 2021
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